Abstract
BackgroundYY-312 is a herbal extract powder from Imperata cylindrica Beauvois, Citrus unshiu Markovich, and Evodia officinalis Dode, which have health promoting effects, including body fat reduction. We aimed to evaluate the efficacy and safety of YY-312 for body fat reduction in overweight adults.MethodsThis was a 12-week, randomized, double-blind, placebo-controlled, parallel-group clinical trial performed in overweight Korean adults aged 19–60 years with a body mass index of 25.0–29.9 kg/m2. The daily dose of YY-312 was 2400 mg (containing 1800 mg of active herbal extract and 600 mg of cyclodextrin). Primary outcomes were reductions in body fat mass (BFM) and body fat percentage (BF%) after 12 weeks. Secondary outcomes included reductions in body weight and waist circumference (WC) after 12 weeks.ResultsAfter 12 weeks, BFM (1.6 kg vs. 0.1 kg; P = 0.023) and BF% (1.5% vs. -0.2%; P = 0.018) decreased significantly more in the YY-312 group than in the placebo group, as did body weight (2.7 kg vs. 1.0 kg; P = 0.014) and WC (2.2 cm vs. 0.8 cm; P = 0.049). All safety parameters were within normal limits; no serious adverse events occurred in either group.ConclusionsIn a 12-week clinical trial in overweight adults, YY-312 resulted in significantly greater reduction in body fat vs. placebo, while being safe and well tolerated.Trial registrationcris.nih.go.kr: (KCT0001225).
Highlights
YY-312 is a herbal extract powder from Imperata cylindrica Beauvois, Citrus unshiu Markovich, and Evodia officinalis Dode, which have health promoting effects, including body fat reduction
Subjects Korean adults aged 19 to 60 years, with a body mass index (BMI) of 25.0–29.9 kg/m2 were recruited between April and August 2014, by advertisements on the Seoul Metro
We excluded: individuals who were suspected of having a medical condition that prevented them from participating in the trial, individuals who were suspected of having a major psychiatric disorder, individuals who were taking drugs or herbal preparations known to significantly affect body weight, pregnant or breastfeeding women, and/or individuals who had recently participated in another clinical trial
Summary
YY-312 is a herbal extract powder from Imperata cylindrica Beauvois, Citrus unshiu Markovich, and Evodia officinalis Dode, which have health promoting effects, including body fat reduction. We aimed to evaluate the efficacy and safety of YY-312 for body fat reduction in overweight adults. Obesity is a condition involving excessive accumulation of body fat that may impair health. In 2014, over 1.9 billion adults worldwide were overweight, of which more than 600 million were estimated to be obese [1]. Obesity leads to an increase in socioeconomic burden. The total socioeconomic costs of overweight and obesity in Korean adults in 2005 were estimated to be approximately US$1.8 billion, equivalent to 3.7% of the national health care expenditure for that year [3]. Hammond et al [4] suggested that the total annual economic costs associated with obesity in the United States are in excess of US$ 215 billion. Development and implementation of cost-effective interventions for obesity prevention and management are essential to reduce the huge economic burden of obesity [5]
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