Abstract
A vasoactive peptide known to increase vascular permeability and corresponding to residues 30–43 of the human fibrinogen Bβ-chain induced polymorphonuclear leukocyte emigration in rabbit skin in vivo . The leukocyte emigration was much stronger after 2 h than after 0.5 h. Addition of prostaglandin E 2 (PGE 2) did not influence the chemotactic activity, which might possibly be explained by a known PGI 2 releasing capacity of this peptide. PGE2 enhanced the leukocyte emigration due to leukotriene B4.
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