Abstract
Effect of Aspergillus oryzae (CAO) culture on systemic inflammatory response and mRNA expression of immune-related mediators in intestine was studied in male broiler chicks. Feeding CAO alleviated enhancement of early inflammatory response such as changes in acute phase substance and growth performance during immunological stress induced by lipopolysaccharide and Sephadex. Furthermore, changes in mRNA expression of immune-related mediators in the upper and lower intestine at 5 and 14 days of age were investigated in chicks fed a diet with antibiotics, CAO or without both as control. The CAO and antibiotic feeding lowered interferon (IFN)-γ and interleukin (IL)-1β mRNA expression compared to the control group. The expressions of toll like receptor (TLR)-4 mRNA in the antibiotic and CAO fed group were greater than that of the control group at 5 days of age, but not at 14 days of age. The findings suggest that CAO has anti-inflammatory effect and changes in IFN-γ, IL-1β and TLR-4 mRNA in immune-related cells of the gut in the CAO fed chicks appears to be similar to that of the antibiotics fed group. These immune-related mediators in the intestine may be a useful marker to select alternative to antibiotics.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
