Effect of a Course of Resistance Training on the Serum Levels of Interleukin-17 and Interferon-β in Women with Multiple Sclerosis

Abstract

Cytokines play an important role in my disease and are considered an important target for therapeutic interventions. the purpose of this research is to investigate the effect of a period of resistance training on the serum level of 17 and interferon beta in young women with MS. Was. Method: The present study was conducted in a semi-experimental way with a pre-test and post-test design. 30 women with MS with age range of 30-35 years were randomly selected in two exercise and control groups. Resistance exercises were performed for 8 weeks and three sessions a week, each session lasting 60 minutes with an intensity of 60-70% of the maximum heart rate. Blood samples were taken before and after the training protocol with 12 hours of fasting and the levels of interleukin 17 and beta interferon were measured by ELISA method. Data were analyzed using SPSS version 22 software and covariance test. Results: The results showed that after 8 hours of resistance training intervention, the amount of interleukin 17 in the training group decreased significantly and the amount of beta interferon showed a significant increase compared to the control group Conclusion: Since moderate intensity resistance training decreased interleukin 17 and increased beta interferon in patients with MS, it seems that exercise intervention can be used to treat and prevent the progression of MS along with used drug treatments.