Abstract
The influence of a copper IUD on the incorporation of [3H]thymidine and [5-3H]uridine into the endometrium of the rabbit was studied during early pregnancy. The effect of the copper device was compared with those of polyethylene and platinum IUDs. The comparison showed that the presence of a copper IUD resulted in a significantly lower incorporation of [3H]thymidine on the 3rd day of pregnancy and in a higher incorporation of [3H]thymidine and [5-3H]uridine on the 5th day of pregnancy. The increase in the total amount of DNA in the endometrium in early pregnancy was markedly reduced in the copper IUD-containing horn, and autoradiography showed that the labelling frequency of epithelial cells in the endometrium was significantly reduced. A possible effect of the copper IUD on the stromal cells is discussed. These effects of copper could be due either to an altered hormonal responsiveness of the endometrium in the presence of copper or to a 'direct' effect of copper on nucleic acid metabolism.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
