EFFECT OF A COMPLEX ACTION OF OZONETHERAPY COMBINED WITH AUTOLOGOUS PLATELET-RICH PLASMA APPLICATION ON THE CHARACTER OF MORPHOFUNCTIONAL CHANGES OF THE TISSUE MACROPHAGES IN PATIENTS WITH DIABETIC FOOT SYNDROME

Abstract

Summary. Objective: to study the character of ultrastructural changes in the tissue macrophages under the effect of a complex of auxiliary factors promoting reparative process activation in the wound including ozonetherapy, local application of autologous platelet-rich plasma (PRP) and vacuum therapy.
 Materials and methods. The patients examined were divided into three groups. The first group included 23 (32,85%) patients who were treated by means of regional ozone therapy. The second group included 23 (32,85%) patients treated by means of local PRP therapy. The control group included 24 (34,28%) patients who during the postoperative period received a complex of therapeutic measures according to the generally accepted method.
 Results. Stimulation of the macrophage functional activity under ozone effect with destructive changes found in the cells without necrotizing damage was found tobe explained by apoptosis mechanism involvement as a positive factor in the regulation of local homeostasis on completion of inflammatory (exudative) phase of the wound process.
 Conclusions. A complex of such auxiliary therapeutic measures confirm more determined level of the reparative process activation on the level of the tissue macrophages in both groups examined (№ 1 and №2) in comparison with the control one.
 Prospects of further research. The results obtained confirm and determine further necessity to carry out search in novations in the treatmen to diabetic foot syndrome using the factors of physical and biological effect directed to the activation of the wound reparative process.