Effect of a brain extract on turnover rate of serum cholesterol.

Abstract

SummaryIn radioisotope studies in the chick and the dog, the turnover rate of the serum cholesterol, as measured by the biological decay of endogenously labeled C14 cholesterol, was substantially increased by the feeding of a cerebroside-rich extract of mammalian brain. Much less influence was found on the turnover rate of P32 labeled phospholipids. Some evidence is presented to suggest that the increased turnover rate of serum cholesterol is produced by an increased fecal excretion of endogenous cholesterol.