Abstract
Abstract Administration of graded doses of 9-α-fluorocortisol to adrenalectomized rats given choice between water and 0.15 M NaCl solution to drink yielded a U-shaped dose-response relationship between percentage change in intake of NaCl solution and dose of hormone administered. Maximal reduction in NaCl intake occurred when 5 μg/100 g body weight/day was administered. Doses greater than this increased NaCl intake toward that of untreated controls. Percentage change in water intake following drug administration was an approximate mirror image of NaCl intake. The results provide further evidence that compounds containing mineralocorticoidlike activity influence the spontaneous NaCl intake of adrenalectomized rats.
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