Abstract
Unilateral injection of 25 ng of muscimol into the rat substantia nigra pars reticulata induced contralateral circling. Circling induced by 25 ng of muscimol was increased by simultaneous administration of 1 μg of Δ 9-tetrahydrocannabinol and abolished by 10 μg. Previous experiments have shown that Δ 9-tetrahydrocannabinol enhances muscimol-induced catalepsy in the globus pallidus. These results identify another brain area in which synergism between Δ 9-tetrahydrocannabinol and muscimol can occur and show that Δ 9-tetrahydrocannabinol can enhance an excitatory as well as an inhibitory GABAergic motor effect. The data support the hypothesis that cannabinoids can facilitate transmission along central γ-aminobutyric acid (GABA) releasing pathways.
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