Abstract
Objective: This study aimed to observe the effect of the 70% ethanol extract of Orthosiphonis stamineus Benth leaves on the pharmacokineticparameters of furosemide in white male rats.Methods: 18 Sprague–Dawley male rats were divided into three groups: The normal control group was given only 1% carboxymethyl cellulose,the furosemide group was given 7.2 mg/200 g body weight (BW) suspension of furosemide, and the combination group was given 700 mg/kg BWsuspension of the 70% ethanolic extract of O. stamineus Benth leaves for 4 days followed by a 7.2 mg/200 g BW suspension of furosemide. On the4th day of treatment, we performed orbital sinus blood sampling on the eyes of the rats and analyzed the levels of furosemide in plasma using highperformanceliquid chromatography.Results: Therefore, the results showed that the administration of the 70% ethanol extract of O. stamineus Benth leaves improves the pharmacokineticparameters of furosemide on Cpmax and the area under the curve (p<0.05).Conclusion: This study concludes that the 70% ethanol extract of O. stamineus Benth leaves improves the pharmacokinetic parameters of furosemidein white male rats.
Highlights
Furosemide is an anthranilic acid derivative drug included in powerful diuretics
Based on the research conducted by Bragatto et al [1], a single dose of 40 mg furosemide given orally produced significant results in increasing the volume of urine and had a pharmacokinetics ratio interval of Cmax (93.63-121.92%), area under the curve (AUC0−t) (96.80-115.72%), and AUC0−∞ (98.45-117.43%)
Another study mentions that the administration of furosemide with a dose of 8 mg/200 g body weight (BW) produced AUC0−∞ 13.52±52.29 μg/mL hr with Cmax 22:34±4:39 μg/mL [2]
Summary
Furosemide is an anthranilic acid derivative drug included in powerful diuretics. Based on the research conducted by Bragatto et al [1], a single dose of 40 mg furosemide given orally produced significant results in increasing the volume of urine and had a pharmacokinetics ratio interval of Cmax (93.63-121.92%), area under the curve (AUC0−t) (96.80-115.72%), and AUC0−∞ (98.45-117.43%). Another study mentions that the administration of furosemide with a dose of 8 mg/200 g body weight (BW) produced AUC0−∞ 13.52±52.29 μg/mL hr with Cmax 22:34±4:39 μg/mL [2]. Cat’s whiskers is a medicinal plant that has been empirically shown to act as a diuretic. Tensigard® is a phytopharmacological preparation containing extracts of cat’s whiskers leaves combined with celery extract and is used as an antihypertensive due to its diuretic properties
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