Abstract
In order to determine the mechanism whereby intramuscular injection of a long-acting medroxyprogesterone inhibits ovulation, daily immunoassay of urinary excretion of LH was performed on 4 subjects. During two control cycles prior to treatment, a midcycle peak of LH excretion was observed at the approximate time of ovulation in all subjects. After treatment with 150mg. of Depo-Provera, there was no peak of LH excretion observed in any subject during the time the drug was active. In the two subjects who had assays continued until ovulation resumed, there was again evidence of a peak in LH excretion at the time of ovulation. This study indicates that medroxyprogesterone acetate administered in this dosage acts as a contraceptive by inhibiting release of LH.
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