Abstract
5′-deoxy-5′-S-isobutyl-adenosine (SIBA), an analogue of S-adenosyl-homocysteine, inhibits the growth of mouse mammary cells transformed by mouse mammary tumour virus (MMTV) and the synthesis of MMTV particles in confluent cells. This compound modifies also the activity of reverse transcriptase (RNA dependent DNA polymerase) associated with MMTV particles. The stimulation of MMTV synthesis by dexamethasone is suppressed with low concentrations of SIBA.
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