Abstract
The effect of several androgens on initiation and maintenance of spermatogeneSis was studied in newborn estrogen-blocked and in adult hypophysectomized rats. The steroid treatment inhibited testicular and body weight in all animals. Treatment of estrogen-blocked animals with androgens resulted in a stimulation of the growth of sex accessory organs, except in the case of androsterone. Initiation of spermatogenesis and its progression to mid pachytene stage (first wave) was observed in all steroid treated rats. In estrogen-blocked animals the first wave of spermatogenesis proceeded only to pachytene spermatocytes. Administration of testosterone propionate. dihydrotestosterone or 5a-androstanediol to these animals resulted in completion of meiosis and formation of spermatids up to Step 8 of spermiogenesis. Completion of meiosis was not observed in androsterone treated rats. In hypophysectomized animals all 5a-reduced androgens maintained spermatogenesis similar to testosterone.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
