Abstract
INCORPORATION of 5-fluorouracil (FU) into TMV particles is claimed to exert a number of biological effects. Although the ability to initiate local lesions by equal quantities of normal and FU substituted virus is not significantly different, less virus is produced in a systemic host when substituted TMV is used as the inoculum1. Another aspect of FU incorporation is the increased sensitivity of substituted virus towards ultra-violet irradiation2. In the last case at least, the biological response could be traced to the altered nucleic acid component of the virus, in analogy to biological systems of higher organization3,4.
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