Abstract
Objective To systematically review the effect of ω-polyunsaturated fatty acids-supplemented nutrition support on the immune function and nutritional status of patients with gastrointestinal malignancies. Methods Databases of MEDLINE, EMBASE, Cochrance Central register of controlled trials, China National Knowledge Infrastructure (CNKI), China Biology Medicine disc (CBM) were searched. The search words were omega-3 polyunsaturated fatty acids, fish oil, cancer, turmor, neoplasms in English or Chinese. All the high quality randomized controlled trials were included after assessed with Jadad scale. RevMan 5.2 was used for statistical analysis. Results Altogether 12 studies were included. Meta-analysis results showed that CD4+%(I2=0%, 95% CI=3.44~6.93, Z=5.82, P<0.000 01), CD8+%(I2=0%, 95% CI=2.44~7.13, Z=4.00, P<0.000 1), CD4+%/CD8+%(I2=74%, 95% CI=0.16~0.83, Z=2.87, P=0.004), IgA (I2=14%, 95% CI=0.21~0.43, Z=5.84, P<0.000 01), prealbumin (I2=0%, 95% CI=0.02~0.05, Z=3.94, P<0.000 1) in the treatment group were higher than in the control group, C-reactive protein (I2=76%, 95% CI=-21.33~-5.03, Z=3.17, P=0.002) in the treatment group was lower than in the control group, the differences were all statistically significant. But there were no statistically significant differences in CD3+%(I2=0%, 95% CI=-3.50~2.56, Z=0.31, P=0.76), IgG (I2=92%, 95% CI=-0.32~5.54, Z=1.74, P=0.08), IgM (I2=99%, 95% CI=-0.52~1.89, Z=1.11, P=0.27), total protein (I2=0%, 95%CI=-4.08~1.77, Z=0.78, P=0.44), albumin (I2=29%, 95% CI=-0.87~1.45, Z=0.49, P=0.63), transferrin (I2=0%, 95% CI=-0.23~0.19, Z=0.19, P=0.85) between treatment and control groups. Conclusion Omega-3 polyunsaturated fatty acids can improve the perioperative immune function of patients with gastrointestinal malignant tumor, reduce inflammatory and stress reactions, but have no obvious effect on the improvement of the nutritional status. Key words: Omega-3 polyunsaturated fatty acid; Cancer; Perioperative; Immune function; Nutritional status; Meta-analysis
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