Effect of 3,4-trans-2, 2-dimethyl-3-phenyl-4-p-(β -pyrrolidinoethoxy) phenyl -7-methoxy chroman (centchroman) on the biochemistry of the fallopian tube and uterus of rhesus monkeys ( [formula omitted

Abstract

Daily oral administration of 3, 4-trans-2, 2-dimethyl-3-phenyl -4-p(β -pyrrolidinoethoxy)-phenyl-7-methoxy chroman (Centchroman) to rhesus monkeys at the antifertility dose (0.625 mg/kg) for 22 days in a cycle produced no change in the weight of the Fallopian tube, ovary, adrenal and pituitary. However, the weight of uterus was significantly increased. The levels of glycogen and protein recorded a marked rise in the Fallopian tube but the concentration of non-protein nitrogen (NPN) was not changed. On the other hand, the level of lactic acid recorded a significant fall. In the uterus, the concentration of lactic acid, glycogen, protein and NPN showed similar changes as in the Fallopian tube. The level of total phospholipid was Markedly elevated as a result of the treatment. No change of the activities of β -glucuronidase and acid and alkaline phosphatases in the Fallopian tube and uterus was detectable. However, the Fallopian tube registered a marked stimulation of the activities of ATPase and malic dehydrogenase (MDH) but a significant fall in the activity of lactic dehydrogenase (LDH). In the uterine tissue, on the other hand, there was a significant increase in the activities of ATPase, 0-6-PD, LDH and MDH. The reported antifertility effect of the compound appears to be principally due to some estrogen-type of biochemical responses that the compound is capable of evoking in the Fallopian tube and uterus.