Abstract
The uptake of 2,5-dimethoxy-4-methylamphetamine (DOM, STP) into rabbit blood platelets and the effect of DOM on uptake and release of 5-hydroxytryptamine (5-HT) from platelets have been investigated. Tritium labeled DOM was taken up slightly against the concentration gradient. DOM in concentrations ranging from 5 × 10 −5 to 1 × 10 −3 M did not affect 14C-5-HT uptake into platelets. However, it increased the 14C-5-HT release from platelets by 100 and 300% at 2 × 10 −4 and 1 × 10 −3 M respectively when platelets were incubated in Krebs-Ringer phosphate buffer, but exerted no effect on the release of 14C-5-HT from the platelets when incubated in 0.9% saline. The mechanism and significance of the increase of 14C-5-HT release from platelets by DOM were discussed.
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