Abstract
There is no information regarding the effects of simulated microgravity or lunar gravity on reserve possibilities of different inspiratory muscles. As a part of the multi-disciplinary “SELENA-T” Bed Rest Study, we investigated the pattern of inspiratory muscles fatigue in twenty-two healthy male subjects during incremental exercise test to exhaustion before and repeatedly after 21-days of hypokinesia by bed rest. Ten subjects underwent all 21 days of hypokinesia on head-down bed rest (HDBR) at a -6 degrees angle simulating microgravity. Twelve subjects spend the first five days of hypokinesia on HDBR and subsequent sixteen days - in head-up bed rest (HUBR) at a +9.6 degrees angle as a supposed analogue of lunar gravity. Maximal inspiratory pressure (MIP) and EMG-analyses of the diaphragm (D), parasternal (PS), sternocleidomastoid (SCM) and scalene (SC) muscles served as indices of inspiratory muscle function assessment. The before-to-after exercise decreases in MIP and centroid frequency (f c ) of the EMG (D, PS, SCM, and SC) power spectrum (P
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