Abstract
In various pathological processes (such as atherosclerosis, ischemia, thrombosis, and endotoxin shock), the membranes of the blood formative elements undergo structural and functional changes [i, 2, 7]. Pharmacological intervention aimed at increasing the stability of thecell membranes enables their sensitivity to be controlled and the pathological changes arising therein (notably enhancement of the peroxide oxidationof lipids) to be eliminated. Continuing studies of biologically active organylthio(sulf onyl)acetic acids [3] in a search for new membrane-stabilizing agents, we have synthesized some 2-hydroxyalkylammonium salts of arylthio- and arylsulfonylacet ic acids, together with esters of these acids (I-XV). The compounds were synthesized by reacting the appropriate acids with alkanolamines in equimolar proportions:
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