Effect Of 12-weeks Of Moderate Versus High-intensity Interval Exercise Training On Postprandial Lipemia, Vascular Function And Arterial Stiffness After High-fat Meal Ingestion In Inactive Adults

Abstract

PURPOSE: The aim of this study was to determine the effect of 12-weeks of moderate continuous training (MCT) and high-intensity training (HIT) on postprandial lipemia, vascular function and arterial stiffness after high-fat meal (HFM) ingestion in inactive adults. METHODS: A randomized clinical trial was conducted in 20 healthy, inactive aged adults (31.6 ±7.1 years). Participants completed two exercise protocols, namely, HIT and MCT, for 12 weeks. To induce a state of postprandial lipemia (PPL), all subjects received an HFM containing 1049 kcal, 31 g of protein, 79 g of fat (31 g of saturated fat), 666 mg of cholesterol and 69 g of carbohydrates. Endothelial function was measured using flow-mediated vasodilation (FMD), normalized brachial artery FMD (nFMD), aortic pulse wave velocity (PWV) and augmentation index (AIx). Plasma total cholesterol, High-density lipoprotein cholesterol (HDL-c), triglycerides and glucose were also measured. The effects of the HFM were measured in a fasted state and 60, 120, 180, and 240 minutes postprandially. RESULTS: The area under the curve from 0 to 240 minutes [AUC (0-240)] for glucose was lower after HIT than after MCT (10%, P=0.008). FMD and nFMD AUC (0-240) were increased in HIT compared with MCT (46.9%, P=0.021 and 67.3%, P=0.009, respectively). Regarding between-group differences, the results showed for glucose, and nFMD. In addition, the average delta of nFMD value was significantly higher in HIT than MCT (P = 0.03) CONCLUSIONS: Supervised exercise-training mitigate endothelial dysfunction and glucose response induced by PPL. Exercise intensity plays an important role in these protective effects, suggesting that HIT might be more effective than MCT in reducing postprandial glucose levels and attenuating vascular impairments.