Abstract
BackgroundInterorgan communication networks established during exercise in several different tissues can be mediated by several exercise-induced factors. Therefore, the present study aimed to investigate the effects of resistance-type training using elastic band-induced changes of myomiRs (i.e., miR-206 and miR-133), vitamin D, CTX-I, ALP, and FRAX® score in elderly women with osteosarcopenic obesity (OSO).MethodsIn this randomized controlled trial, 63 women (aged 65–80 years) with Osteosarcopenic Obesity were recruited and assessed, using a dual-energy X-ray absorptiometry instrument. The resistance-type training via elastic bands was further designed three times per week for 12-weeks. The main outcomes were Fracture Risk Assessment Tool score, bone mineral content, bone mineral density, vitamin D, alkaline phosphatase, C-terminal telopeptides of type I collagen, expression of miR-206 and miR-133.ResultsThere was no significant difference between the study groups in terms of the Fracture Risk Assessment Tool score (p = 0.067), vitamin D (p = 0.566), alkaline phosphatase (p = 0.334), C-terminal telopeptides of type I collagen (p = 0.067), microR-133 (p = 0.093) and miR-206 (p = 0.723).ConclusionOverall, the results of this study illustrated 12-weeks of elastic band resistance training causes a slight and insignificant improvement in osteoporosis markers in women affected with Osteosarcopenic Obesity.Trial registrationRandomized controlled trial (RCT) (Iranian Registry of Clinical Trials, trial registration number: IRCT20180627040260N1.Date of registration: 27/11/2018.
Highlights
Interorgan communication networks established during exercise in several different tissues can be mediated by several exercise-induced factors
Emerging evidence indicates that muscle-bone communication may be achieved by the release of some myotube-derived exosomal microRNAs to neighboring cells [6], and myomiRs can further transport health-promoting information of exercise interventions to other tissues in endocrine and paracrine manners [7] so that myomiRs can be released into the blood serum/plasma, wherein their levels are influenced by exercise and diseases [5, 8]
No more significant side effects were reported by researchers who were not blinded during the 12-week intervention than the group assignment
Summary
Interorgan communication networks established during exercise in several different tissues can be mediated by several exercise-induced factors. The term osteosarcopenic obesity (OSO) has been recently proposed for the relationship between losses of muscle and bone mass and increased fat mass [1,2,3] Both bone and skeletal muscle share similar mesenchymal origins and respond to trophic effects of hormones, growth factors, inflammatory mediators, loading and exercise training [4], as well as communication via paracrine/endocrine factors [5]. Emerging evidence indicates that muscle-bone communication may be achieved by the release of some myotube-derived exosomal microRNAs (myomiRs) to neighboring cells [6], and myomiRs can further transport health-promoting information of exercise interventions to other tissues in endocrine and paracrine manners [7] so that myomiRs can be released into the blood serum/plasma, wherein their levels are influenced by exercise and diseases [5, 8]. An et al had demonstrated that expression of some myomiRs (i.e., 133a, 206, and 204) had changed in the bone tissue of ovariectomized mice [9]
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