Abstract
The effect of low-dose 1α-hydroxyvitamin D 3 [1α(OH)D 3] on experimental osteoporosis in rats induced by a combination of hemicordotomy and ovariectomy was evaluated. 1α(OH)D 3 (0.1 μg/kg 1α(OH)D 3 three times a week) increased the femur score and photo-density. The administration of 1α(OH)D 3 also significantly increased the dry weight and ash weight of the bone. Histomorphometry revealed a significant decrease of bone resorption by the administration of 1α(OH)D 3. Significant decreases in 45Ca accretion rate and 14C-proline uptake were also observed. Bone formation in the 1α(OH)D 3 treated group was thought to decrease following the decrease of bone resorption.
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