Abstract
The effect of low-dose 1α-hydroxyvitamin D 3 [1α(OH)D 3] on experimental osteoporosis in rats induced by a combination of hemicordotomy and ovariectomy was evaluated. 1α(OH)D 3 (0.1 μg/kg 1α(OH)D 3 three times a week) increased the femur score and photo-density. The administration of 1α(OH)D 3 also significantly increased the dry weight and ash weight of the bone. Histomorphometry revealed a significant decrease of bone resorption by the administration of 1α(OH)D 3. Significant decreases in 45Ca accretion rate and 14C-proline uptake were also observed. Bone formation in the 1α(OH)D 3 treated group was thought to decrease following the decrease of bone resorption.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.