Abstract
The effects of intravenous infusion of epinephrine on the coronary circulation of 21 human subjects, 8 with and 13 without coronary artery disease, have been studied. The response to epinephrine was similar in the two groups. Epinephrine increased cardiac output, stroke volume, and systolic ejection rate significantly without significant change in blood pressure. Myocardial O 2 consumption increased in relation to increased kinetics of contraction. Coronary flow increased significantly without change in coronary arteriovenous O 2 difference, suggesting that the vasodilatory response to epinephrine in man is secondary to augmented myocardial metabolic demands.
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