Abstract
Objective To explore the effects of 1, 25-dihydroxyvitamin D3 on renal expression of TGFβ1, Smad3 and Smad7. Methods 40 Sprague-Dawley rats were randomized into 4 groups: normal control rats(group A), diabetic nephropathy group(group B), small dose 1, 25-dihydroxyvitamin D treatment group(0.5μg·kg-1·d-1, group C) and large dose 1, 25-dihydroxyvitamin D treatment group(1μg·kg-1·d-1, group D), each group had 10 rats.After 12 weeks, the renal function, blood glucose, glycosylated hemoglobin and the urine trace albumin content of each rats were tested. Results The biochemical indicators in group B were higher than those in group A, (t=-16.566, P 0.05; t=1.737, P>0.05; t=0.671, P>0.05; t=1.763, P>0.05; t=0.997, P>0.05; t=1.653, P>0.05; t=1.543, P>0.05; t=-1.313, P>0.05). Conclusion 1, 25-dihydroxyvitamin D3 has protective effect on diabetic nephropathy rats model, the mechanism may be associated with inhibiting the expression of TGF β1 and Smad3, increasing the expression of Smad7. Key words: 1, 25-dihydroxyvitamin D3; Diabetic nephropathy; Transforming growth factor betal
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