Effect of 0.01% Atropine on Accommodation in Myopic Teenagers.

Huixia Li,Liying Zhang,Yujing Chen,Xiaoying Wu,Lei Liu,Hongmei Jiang,Wenping Qi,Song Zhang,Yajun Yang,Hailong Yang,Hong Tian,Han Zhang,Guisen Zhang,Xueyan Zhang

doi:10.3389/fphar.2022.808440

Abstract

Purpose: The purpose of the study is to evaluate the effects of 0.01% atropine eye drops on accommodative system parameters among teenagers with low myopia. Methods: Ninety-five myopic teenagers [39 boys (8.69 ± 2.473) and 56 girls (8.54 ± 2.054) aged 5–17 years] with no history of eye disease were enrolled. Biometric and accommodative system parameters were evaluated before and at 1 week, 1 month, 3 months, and 6 months of 0.01% atropine eye drop instillation. Results: Participants without accommodative demand at 6 months demonstrated insignificant changes after the atropine instillation (all p > 0.05). Nevertheless, there were significant differences in accommodative sensitivity, accommodative amplitude, accommodative responsiveness, and negative relative accommodation (NRA) at 3 months compared with baseline after atropine instillation (all p < 0.05). Except spherical equivalent refraction, cornea thickness, intraocular pressure, and axial length were stable after the 0.01% atropine instillation (all p > 0.05). Conclusion: Morphologically, current measurements suggested that 0.01% atropine had favorable reduction of accommodation for childhood low myopia over a half-year period.

Highlights

Myopia has become a significant global public health and socioeconomic problem (Xue et al, 2018)
Ninety-five teenagers [39 boys (8.69 ± 2.473) and 56 girls (8.54 ± 2.054)] all underwent 0.01% atropine treatment, and no severe complications were observed during the follow-up period
The cycloplegic refraction of the right eye ranged from −2.75 D to 0.25 D, and that of the left eye ranged from −2.25 D to 1.875 D; there was no significant difference in refraction between the right and left eyes (p = 0.133)

Summary

Introduction

Myopia has become a significant global public health and socioeconomic problem (Xue et al, 2018). Several studies report that the occurrence and progression of myopia are related to accommodation (Holden et al, 2014; Jonas et al, 2021). Atropine can be used for cycloplegia before optometry, and the treatment of amblyopia, iridocyclitis, and malignant glaucoma (Chen et al, 2021; Pineles et al, 2021). In recent years, this “old drugs” with new application was used to control myopia (Saw et al, 2002; Chia et al, 2016; Hieda et al, 2021).

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