Abstract
The taste reactivity test was employed to determine the effect of pre-treatment with Δ 9-Tetrahyrdrocannabinol THC on sucrose palatability. In Experiment 1, on each of 9 trials, rats were injected with THC or Vehicle prior to receiving a 5 min intraoral infusion of sucrose solution. The concentration of sucrose (2%, 10% or 32%) and the interval between the injection and the sucrose infusion (30, 60 or 120 min) were varied in a within-subjects design. THC enhanced the frequency of ingestion reactions only when administered 120 min prior to the taste reactivity test, regardless of sucrose concentration. In Experiment 2, the CB 1 antagonist, SR141716, reversed the enhanced sucrose palatability produced by THC. These results suggest that the increased intake of palatable food 2 h, but not earlier, following administration of a low dose of THC may be the result of enhanced palatability and that this effect is the result of action of THC at the CB 1 receptor.
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