Abstract
Objective. To investigate whether ω-3 fatty acid could stimulate gastrointestinal motility after abdominal operation. Method. Wistar rats were randomly divided into 3 group (normal saline group, intralipid group, and ω-3 fatty acid group, n = 18/group) after partial caecectomy and gastrostomosis, each group was divided into 3 groups (POD1, POD3, and POD6, n = 6/group). Serum gastrin (GAS), motilin (MTL), interleukin-1 (IL-1), interleukin-6 (IL-6), tissue necrosis factor-α (TNF-α), cyclooxygenase-2 (COX-2), gastric emptying rate, and small bowel propulsion rate were measured. Results. On POD 3, gastric emptying rate and small bowel propulsion rate in ω-3 fatty acid group were higher than those in normal saline group and intralipid group. Serum GAS and MTL levels in ω-3 fatty acid group were higher than those in normal saline group, but serum IL-1, IL-6, TNF-α, and COX-2 levels were lower than those in normal saline group and intralipid group. Conclusion. ω-3 fatty acid could accelerate the recovery of gastrointestinal mobility after abdominal operation in rats, mainly by relieving postoperative inflammation.
Highlights
Postoperative gastrointestinal motility dysfunction is a frequent complication of laparotomy, especially after gastrointestinal operation
Conclusion. ω-3 fatty acid could accelerate the recovery of gastrointestinal mobility after abdominal operation in rats, mainly by relieving postoperative inflammation
Our research showed that on POD 3, the serum GAS and MTL levels in ω-3 fatty acid group were higher than those in normal saline group, but there was no difference between ω-3 fatty acid group and intralipid group
Summary
Postoperative gastrointestinal motility dysfunction is a frequent complication of laparotomy, especially after gastrointestinal operation. It may cause small bowel obstruction, serious infection, hepatic dysfunction, or reoperation with prolonged hospitalization and increased perioperative expenses. During parenteral nutrition or enteral nutrition, numerous hormones secreted by the gut influence gastrointestinal motor, and appear to contribute to the pathogenesis of gastrointestinal motility dysfunction [1]. Cyclooxygenase-2 (COX-2) is the key enzyme of prostaglandin synthesis in inflamed tissues It can affect the motor activity of gastrointestinal tract in postoperative ileus, and COX-2 inhibitors could help to improve the outcome of this gut disorder [3, 4]
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