Effect observation of magnesium isoglycyrrhizinate combined with pantoprazole and somatostatin in the treatment of severe acute pancreatitis

Abstract

Objective To investigate the efficacy and safety of magnesium isoglycyrrhizinate combined with pantoprazole and somatostatin in the treatment of severe acute pancreatitis (SAP). Methods 123 patients with SAP were randomly divided into group A, group B, and group C. Group A was treated with magnesium isoglycyrrhizinate injection, group B was treated with pantoprazole combined somatostatin, and group C was treated with magnesium isoglycyrrhizinate combined with pantoprazole and somatostatin. The inflammatory indexes such as C reactive protein (CRP), tumor necrosis factor alpha (TNF-α), and interleukin-6 (IL-6), the changes of organ function indexes such as urea nitrogen, alanine aminotransferase, oxygenation index before and after treatment, the abdominal pain relief time, recovery time of gastrointestinal function, and ventilator withdrawal time were compared among the three groups. Results After treatment, the levels of CRP, TNF- α, IL-6 in the group A were respectively (36.5±4.6)mg/L, (28.6±6.5)pg/L, (125.8±30.1)pg/L, those in the group B were respectively (34.7±5.1)mg/L, (29.0±6.2)pg/L, (123.4±28.7)pg/L, those in the group C were respectively (19.4±5.0)mg/L, (22.4±5.7)pg/L, (91.4±20.3)pg/L, the levels of CRP, TNF-α, IL-6 in the three groups were significantly lower than those before treatment (P<0.05), and those in the group C decreased the most obviously (P<0.05). The abdominal pain relief time, recovery time of gastrointestinal function, and ventilator withdrawal time in the group A were respectively (3.2±0.5)d, (3.2±0.9)d, (4.2±0.8)d, those in the group B were respectively (3.3±0.6)d, (3.1±0.8)d, (4.1±0.7)d, those in the group C were respectively (1.7±0.6)d, (2.4±0.6)d, (2.8±0.6)d, the abdominal pain relief time, recovery time of gastrointestinal function, and ventilator withdrawal time in the group C were significantly lower than those in the group A and group B (P<0.05). After treatment, the oxygenation index, the levels of urea nitrogen and alanine aminotransferase in the group A were respectively (310.8±51.3)mmHg, (8.6±2.4)mmol/L, (48.5±10.1)U/L, those in the group B were respectively (315.9±54.0)mmHg, (8.4±2.6)mmol/L, (49.6±9.8)U/L, those in the group C were respectively (463.7±92.0)mmHg, (6.1±1.4)mmol/L, (29.2±8.4)U/L, the oxygenation index in the three groups were significantly higher than those before treatment, the levels of urea nitrogen and alanine aminotransferase were significantly lower than those before treatment (P<0.05), the oxygenation index in the group C was significantly higher than those in the group A and group B (P<0.05). The total effective rate in the group C (90.2%) was significantly higher than that in the group A (68.3%) and group B (68.3%) (P<0.05). Conclusion Magnesium isoglycyrrhizinate combined with pantoprazole and somatostatin in the treatment of severe acute pancreatitis can significantly improve the inflammatory reaction, the clinical signs and symptoms, protect organ function, improve the clinical efficacy, worthy of clinical application. Key words: Magnesium isoglycyrrhizinate; Pantoprazole sodium; Somatostatin; Severe acute pancreatitis