Effect observation of honey and rb-bFGF in promoting the wound healing of oral mucosa

Abstract

Objective To explore the efficacy of honey and recombinant bovine basic fibroblast growth factor (rb-bFGF) in promoting wound healing after the surgery of oral mucosa transplantation, and provide evidence for clinical nursing. Methods Eighty patients who underwent oral mucosa transplant surgery were selected and randomly divided into four groups by random number table method, with 20 cases in each group. Group A was the control group, the oral mucosa wounds were exposed to air and kept clean and dry; in group B, the oral mucosa wounds were treated with honey; in group C, the oral mucosa wounds were treated with rb-bFGF gel; and in Group D, the patients were treated with honey combined with rb-bFGF gel. The wound healing level, eating recovery time, and pain level of four groups were evaluated and compared. Results The comparison in wound healing degree among four groups seven days after surgery was statistically significant different (P<0.05) ; the wound healing level of group D was better than group B and C (P<0.05) ; the pain level of patients in four groups was significantly different (P<0.05) ; the pain level of group D was better than other three groups (P<0.05) ; the comparison of eating recovery time among four groups was significantly different (P<0.05) ; the eating recovery time of group D was better than group B and C (P<0.05) . Conclusions Both honey and rb-bFGFcan effectively promote the wound healing of oral mucosa. The combination of honey and rb-bFGF, can shorten the eating recovery time, relieve pain, and promote wound healing, so as to improve patients' quality of life. Key words: Honey; Recombinant bovine basic fibroblast growth factor; Oral mucosa; Wound healing