Abstract
In this experiment, we aimed to recorded the effect of chronic oral exposure to DEHP on lipid peroxidation and histopathological lesions induced in different organs. A total of 150 quail chick divided into two groups (75 quail’s chicks at each group), control group left without any treatment all time, the second group was orally administrated 5% of DEHP (278.05 mg/kg bw) three times per week and lasted for 60 days. At 30 and 60 days old, a total number of 25 from both groups were euthanized. Blood samples were collected to determine the serum concentration of DEHP and mono ethyl hexyl phthalate (MEHP), liver and kidney to estimate tissue concentration of malondialdehyde (MDA), samples from different organs for histopathological examination. The result showed that the concentration of DEHP and MEHP in blood's serum and concentration of MDA in liver and kidney significantly increased with time in comparison with the control group; besides, oral administration of DEHP induced sever pathological lesions, in brain, aorta, intestines, liver, lung, ovary and testis. In conclusion, the DEHP and its metabolic product MEHP significantly increased in serum and cause significant increase in concertation of MDA in liver and kidney tissues, produces a significant histopathological change in brain, aorta, liver, intestine, lung, ovary and testis that can cause a life-threatening condition.
Highlights
DEHP is considered an environmental pollutant widely distributed worldwide, causing severe health issues for humans and animals [1]
The result showed that the concentration of DEHP and mono ethyl hexyl phthalate (MEHP) in blood's serum and concentration of MDA in liver and kidney significantly increased with time in comparison with the control group; besides, oral administration of DEHP induced sever pathological lesions, in brain, aorta, intestines, liver, lung, ovary and testis
The DEHP and its metabolic product MEHP significantly increased in serum and cause significant increase in concertation of MDA in liver and kidney tissues, produces a significant histopathological change in brain, aorta, liver, intestine, lung, ovary and testis that can cause a life-threatening condition
Summary
DEHP is considered an environmental pollutant widely distributed worldwide, causing severe health issues for humans and animals [1]. DEHP is a member of phthalic acid products used in polyvinyl chloride as a master plasticizer to produce the desired flexibility [2] It is odorless and colorless, mix with water and lipids solvents, to its use as a plasticizer, it adds to industrial color, engine oils, a preservative in cosmetics products; its previously used in tubes and blood bags [3], due to this general industrial uses of DEHP the annual world production is estimated by 20 billion tons [4]. DEHP has a unique chemical reaction with materials added to them; it does not react with other molecules' chemical bonds, but it covers other materials' molecular composition This reaction is solved by exposure to sunlight or temperature above 25oC to water, air, and soil of the surrounding environment, considered the primary source of toxicity DEHP to other livings [8]. We aimed to investigate the pathology associated with oral DEHP administration in the brain, intestines, lungs, testis, and ovary in addition to liver and kidney of quails, study the effect of prolonged exposure to DEHP in quails on peroxidation factors such as MDA, the effect of DEHP administration on the production properties of quails such as food consumption, food conversion ratio and egg production using 5% of LD50 of DEHP
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