Abstract
Objective To investigate the clinical effect of Vitamin E on patients with osteoarthritis (OA) and its effect on oxygen free radical levels. Methods Forty-seven patients (48 knees) with OA were randomly divided into study group[24 cases (24 knees)]and control group[23 cases (24 knees)]. Patients in study group were treated with Vitamin E and sodium hyaluronate injection, and patients in control group were treated with sodium hyaluronate injection. The levels of serum nitric oxide(NO), malondialdehyde (MDA) and superoxide dismutase (SOD) before and after treatment in the two groups were detected; and the function of knee joint were obseroed and evaluated with the Western Ontario and McMaster Universities osteoarthritis index (WOMAC) and index of severity of osteoarthritis (ISOA). Results The levels of NO and MDA in study group were significantly lower than those in control group, but the level of SOD in study group was significantly higher than that in control group (P<0.05). Conclusions Vitamin E can effectively reduce the levels of NO and MDA and increase the activity of serum SOD in osteoarthritis patients, scavenge oxygen free radicals and improve joint function. Key words: Vitamin E; Osteoarthritis; Oxygen free radicals; Superoxide dismutase
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