Effect and safety of primary percutaneous coronary intervention on acute ST-segment elevation myocardial infarction in elderly patients

Abstract

Objective To investigate the effect and safety of primary percutaneous coronary intervention (PCI) of acute ST-segment elevation myocardial infarction (STEMI) in elderly patients. Methods 103 consecutive patients with STEMI treated by primary PCI were divided into two groups according to the age: the elderly group 〔aged≥65 years, with a mean age of (75.7±6.2) years(n = 49), the non-elderly group 〔aged<65 years, with a mean age of (43.0±8.6) years(n = 54). Clinical characteristics, complications related to PCI procedure and success rate were analyzed, and major cardiovascular events (MACE) were followed up for(5.7±1.2)months. Results The proportion of female, patients with Killip ≥Ⅲ, three vessels disease and higher level of serum brain natriuretic peptide were higher in elderly group than in non-elderly group (all P 0.05). Patients were followed up for (5.7±1.2) months. The in-hospital and one-month mortalities were higher in elderly group than in non-elderly group 〔8.2% (4 cases)vs. 0% (0 case), 10.2%(5 cases) vs. 0 % (0 case), respectively, all P<0.05〕. There was no significant difference in six-month mortality and MACE between the two groups. Multivariate logistic regression analysis showed that Killip ≥Ⅲ was related with the increase of one-month mortality in patients with STEMI undergoing primary PCI, whereas age was not. Conclusions Primary PCI is effective and safe in elderly patients with STEMI. Key words: Myocardial infarction; Angioplasty, transluminal, Percutaneous cornary