EFFECT AND MECHANISM OF TRADITIONAL CHINESE MEDICINE HUOLOU GUKANG PILL COMBINED WITH SIMVASTATIN ON STEROID-INDUCED NECROSIS OF FEMORAL HEAD

Abstract

Objectives: Aim of present study was to explore the effect and mechanism of traditional Chinese medicine HuoLou Gukang pill combined with simvastatin on steroid-induced necrosis of femoral head. Methods: A total of 130 patients with steroid-induced necrosis of femoral head treated in our hospital from January 2016 to April 2017 were randomly divided into control group and study group. Each group had 65 cases. Control group were treated with simvastatin, patients in study group were treated with traditional Chinese medicine HuoLuo GuKang pill on the basis of control group. Before and after treatment, patients were tested for adiponectin, TNF-α, blood lipid and blood glucose. Harris score and VAS score were also measured. Results: There was no significant difference in adiponectin, TNF-α, blood glucose, CH, TG, HDL-C and LDL-C between two groups before treatment (P>0.05). After treatment, the levels of adiponectin and HDL-C in study group were significantly higher than those in control group (P 0.05). The Harris score of study group was significantly higher than that of control group after treatment (P 0.05), but there was significant difference in control group (P<0.05). Conclusion: The treatment effect of Chinese medicine HuoLou Gukang pill combined with simvastatin on steroid-induced necrosis of femoral head is better than that of simvastatin. Chinese medicine HuoLou Gukang pills combined with simvastatin can intervene the development of steroid-induced necrosis of femoral head effectively, prevent malignant progress and reduce incidence of patients by reducing blood lipid and improving hemodynamic mechanism, thus it is worthy being popularized and applied. Peer Review History: Received 9 December 2017; Revised 20 December; Accepted 28 December, Available online 15 January 2018 Academic Editor: Dr. Jennifer Audu-Peter, University of Jos, Nigeria, drambia44@gmail.com UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency. Received file: Reviewer's Comments: Average Peer review marks at initial stage: 6.5/10 Average Peer review marks at publication stage: 7.5/10 Reviewer(s) detail: Dr. Sabah Hussien El-Ghaiesh , Tanta University, Egypt, s.ghaiesh@gmail.com Dr. Francis Adou Yapo, Felix Houphouet Boigny, University of Abidjan, Ivory Coast, fyapo@yahoo.fr Similar Articles: ANTIDIABETIC AND ANTIHYPERLIPIDEMIC ACTIVITY OF DRACAENA CINNABARI BALF. RESIN ETHANOLIC EXTRACT OF SOQATRA ISLAND IN EXPERIMENTAL ANIMALS