Effect analysis of alprostadil combined with irbesartan in patients with early diabetic nephropathy

Abstract

Objective To discuss the effect of alprostadil combined with irbesartan in patients with early diabetic nephropathy. Methods Ninety-six patients with early diabetic nephropathy were divided randomly and voluntarily into the control group(n=48) and observation group(n=48). All patients were given regular treatment, the patients of the control group were given irbesartan(150 mg, oral) based on regular treatment while the observation group were given alprostadil(intravenous drip alprostadil 10 g with saline 250 ml, 1 times a day) based on treatment of the control group, the course was four weeks.The blood rheology, serum albumin, 24 hours urinary albumin excretion rate(UAER) and urea nitrogen(BUN), serum creatinine(Scr) and clinical effect between the two groups were compared. Results After treatment, the whole blood midst shear viscosity values, whole blood low shear viscosity values and whole blood high shear viscosity values of observation group were respectively (5.32±1.16) mPa·s, (8.73±2.15) mPa·s and (3.52±0.52) mPa·s, significantly lower than of control group((6.74±1.92) mPa·s, (9.96±2.43) mPa·s, (4.53±0.64) mPa·s), the differences were statistically significant(t=4.627, 4.728, 4.226; P<0.05). The Alb of observation group was (36.36±7.24) g/L, obviously higher than that of control group(29.73±5.36) g/L, the difference was statistically significant(t=5.336, P<0.05), while the UAER, BUN and Scr of observation group were respectively (375.84±24.24) mg/L, (9.61±1.42) mmol/L and (136.36±26.73) μmol/L, obviously lower than that of control group((636.42±43.56) mg/L, (13.45±3.14) mmol/L, (176.32±41.62) μmol/L), the differences were statistically significant(t=6.738, 4.628, 6.662; P<0.05). The total effective rate of observation group was obviously higher than that of control group, the differences were statistically significant(93.75%(45/48) vs.66.67%(32/48); χ2=6.637, P<0.05). Conclusion Alprostadil combine with irbesartan can effectively improve the blood rheology and renal function in patients with early diabetic nephropathy and improve the living quality, the effect is better than irbesartan only, it is worth popularization and application. Key words: Diabetic nephropathy; Alprostadil; Irbesartan; Renal function