Effcts and safety of piperacillin combined with ulinastatin on patients with severe burns

Abstract

Objective To analyze the intervention effects and safety of piperacillin combined with ulinastatin on patients with severe burns. Methods A total of 120 patients with severe burns treated in the Second Peopls’s Hospital of Changzhi from January 2012 to January 2018 were selected as research objects. And they were divided into control group and experimental group by random number table method, with 60 cases in each group. Patients in control group were given piperacillin, while patients in experimental group were given ulinastatin and piperacillin. After treatment, the clinical efficacy, respiratory function, and pulmonary function indexes were compared between the two groups, such as forced vital capacity (FVC), forced expiratory volume in first second (FEV1) and maximum autonomous ventilation (MVV). Treatment safety and levels of serum interleukin-8 (IL-8), interleukin-6 (IL-6), and tumor necrosis factor-α(TNF-α) were compared between the two groups after treatment. Results There was no significant difference in respiratory function, pulmonary function index or levels of serum inflammatory factors between the two groups (P>0.05). The levels of FEV1, FEV1 /FVC and MVV in experimental group were significantly higher than those in control group after treatment (P 0.05). Conclusions Piperacillin combined with ulinastatin has significant efficacy in the treatment of patients with severe burns, which can improve lung function and reduce the levels of serum IL-8, IL-6 and TNF-α. Thus, it is worth further promotion and application. Key words: Piperacillin; Ulinastatin; Severe burns; Safety