EFFCT OF ZINGIBEN OFFICINALE PLANT AND H2O2 ON SOME PHYSIOLOGICAL , HISTOLOGICAL AND BIOCHEMICAL PARAMETERS IN LOCAL MALE RABBITS

Abstract

This study was conducted to investigate the protective effect of Zingiben Officinale against the H2O2 induced oxidative stress in local male rabbits 5 – 6 months old . Rabbits were divided into 4 groups 4 rabbits each . Zingiben officinale was used as capsules at a dose of 1000 mg / kg. B. wt . The rabbits were treated dialy for 28 days . Oxidative stress was determined through measuring the levels of glutathione GSH and malondialdehyde MDA in liver tissue and of ALT and AST enzymes levels . H2O2 treatment showed significant decrease in liver tissue MDA and a significant increase liver tissue GSH serum AST and ALT were significantly increase also the above changes indicate the ability of H2O2 (1 %) in the induction of oxidative stress in local male rabbits .The treatment with zingiben officinale showed the following results significant decrease in ALT and AST serum levels , also significant decrease in liver tissue MDA and significant increase in GSH level , significant decrease in liver fat % These results indicate the protective effect of ZingibenOfficinal against oxidative stress .