Abstract
The tumor marker CA125 is one of the currently used biomarkers to detect ovarian cancer. The tumormarker CA125 also elevated in other diseases. Human epididymis protein 4 is used as a new biomarker forearly detection of ovarian cancer. Human epididymis protein 4 is increased in almost all patients withovarian cancer and increased only slightly at a fraction of other diseases. Human epididymis protein 4 hasa better effectiveness in detecting ovarian cancer when combined with CA125. From the study of literaturefound that the combination of HE4 and CA125 had a specificity of 96.3% and 92.9% sensitivity.
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