Efektifitas Terapi Asam Urat dengan Poliherbal Ekstrak Bawang Merah (Allium ascalonicum L.) dan Jahe Merah (Zingiber officinale var rubrum) pada Tikus Hiperurisemia

Abstract

Uric acid cause inflammation of acute gout arthtritis and other complications. Giving chemical drugs has side effects. Flavonoids in shallots (Allium ascalonicum L.) can inhibit the xanthine oxidase enzyme as antihyperuricemia. Gingerol in red ginger (Zingiber officinale var rubrum) as antihyperuricemia with antiinflammatory effect. The research aims to determine the effectiveness of the polyherbal extract of shallots (Allium ascalonicum L.) and red ginger (Zingiber officinale var rubrum) in hyperuricemia rats. Twenty five of male rats were divided into five goups, namely negative control, positive control, (P1) 25% red ginger extract and 75% shallot, (P2) 50% red ginger extract and 50% shallot, (P3) 75% red ginger extract and 25% shallot. Potassium oxonate 250 mg / kg BW was induced intraperitoneally on the 7 th day. Uric acid has been measured on 14 th , 21 th and 28 th days. On the 15 th to 28 th days, herbs/chemical drugs were administered according to the groups. Data were analyzed using Anova Multifactorial Randomized Design, continued with Post Hoc with the Least Significant Different test. The results showed that administration of potassium oxonate, chemical drugs and combination of herbs extracts had a significant effect (p <0.05) on uric acid levels compare with negative control. The conclusion show that the administration of polyherbal shallot extract (Allium ascalonicum L.) and red ginger (Zingiber officinale var rubrum) indicates as antihyperuricemia . The most effective dose is red ginger extract 450 mg/200 g and shallot 150 mg/200 g BW/day for two weeks of administration.