Abstract
This study aims to determine the hepatotoxic effects of extract ethanol Herba Comfrey the rabbit test animals by measuring levels of SGOT and SGPT. This study used 12 rabbits were divided into 4 groups. The control group (-) given Na.CMC 1% w/v, group I, II, and III were given suspensions of extract ethanol Herba Comfrey with each concentration of 2% w/v, 4% w/v and 8% w/v for 7 days. The results showed that the extract ethanol Herba Comfrey with concentration of 2% w/v, 4% w/v, and 8% w/v effects can cause hepatotoxicity. It is showed from the increase in the average SGOT value in rabbits at 13.96 U/L, 20.63 U/L and 37.13 U/L. and SGPT value of 20.73 U / L, 32.4 U / L and 44.66 U / L. extract Ethanol Herba Comfrey with concentration 8% w / v causes an increase in SGOT and SGPT concentrations higher than the other, and accelerate the liver damage or hepatotoxicity. The higher the concentration, the greater the effect.Keywords: Herba Comfrey, hepatotoxicity, SGOT-SGPT
Highlights
PENDAHULUAN Keberadaan tanaman sebagai obat sudah dikenal sejak ribuan tahun lampau
This study aims to determine the hepatotoxic effects of extract ethanol Herba Comfrey the rabbit test animals by measuring levels of SGOT and SGPT
The results showed that the extract ethanol Herba Comfrey with concentration of 2% w/v, 4% w/v, and 8% w/v effects can cause hepatotoxicity
Summary
PENDAHULUAN Keberadaan tanaman sebagai obat sudah dikenal sejak ribuan tahun lampau. Bukti sejarah ini terukir di helaian lontar, dindingdinding candi, dan kitab masa lalu. Salah satunya dilakukan oleh Amrizal pada tahun 1988 (dalam buku Dalimartha, 2007) tentang Uji Efek Infus Daun Kompri (Symphytum officinale L) Terhadap Kadar Glukosa Darah Tikus Putih Jantan, hasilnya menunjukkan infus daun kompri 20% dengan takaran 25 dan Tujuan penelitian ini untuk mengetahui efek hepatotoksik ekstrak etanol Herba Kompri pada hewan uji kelinci berdasarkan pengukuran kadar SGOT dan SGPT. Suspensi ekstrak etanol Herba Kompri dibuat dengan menambahkan larutan pensuspensi Na.CMC 1% b/v.
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