Abstract
This study was designed to evaluate the hepatoprotective effect of the powder Eurycoma longifolia Jack. From the activity level of SGPT-SGOT on CCl4-induced in male rats. Twenty five male rats (150-250 g) divide in to 5 groups. Group I treated with aquadest was kept as normal, group II treated with a single dose of CCl4 (1 ml/ kg BW i.p), group III and IV were treated with Eurycoma longifolia Jack. (100 mg/kg BW and 200 mg/kg BW p.o) respectively and CCl4 (1 ml/kg BW i.p), group V treated with a single dose of curcumin (100 mg/kg BW p.o) and CCl4 (1 ml/kg BW i.p). Blood was collected from vena porta for determination of SGPT-SGOT. The study showed the activity level of SGPT from the rats was treated by Eurycoma longifolia Jack. 100 mg/kg BW and 200 mg/kg BW, Curcumin, and control groups are 150.0±5.099 U/L; 113.6±5.508 U/L; 60.5±2.887 U/L; and 129.0±6.055 U/L respectively. Mean while the activity level of SGOT from the rats was treated by Eurycoma longifolia Jack. 100 mg/ kg BW and 200 mg/ kg BW, Curcumin, and control groups are 369.4±11.165; 263.0±1.803; 194.5±7.448; and 451.5±16.759 U/L respectively. The Eurycoma longifolia Jack. powder and Curcumin significantly (p < 0.05) declines two enzymes (SGPT and SGOT) than control group. The results concluded that Eurycoma longifolia Jack. powder has hepatoprotective effect.
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