Abstract
To evaluate the effects of the Andiroba (carapa guianensis) oil on liver function in rats subjected to normothermic ischemia / reperfusion injury. we divided 12 Wistar rats into two groups: saline (n = 6) and Andiroba (n = 6). The Andiroba group was treated with Andiroba oil (0.63 ml/kg orally) for seven days before surgery. Ischemia was induced by occlusion of the blood supply to the lateral and median lobes of the liver, using vascular clips, in both groups, for 45min, followed by reperfusion for 60 minutes later. We analyzed dosages of AST, ALT, Gamma-GT, and liver biodistribution of 99mTc phytate. There was no significant difference in the percentage of radioactivity / gram of tissue (%ATI/g) in the right lobe of the saline group (17.53 ± 2.78) compared with the Andiroba group (18.04 ± 3.52) p = 0.461, the same occurring in the%ATI/g of the left lobe of the liver when the two groups were compared (p = 0.083). In the saline group, the%ATI/g was significantly higher in the non-ischemic right hepatic lobe (17.53 ± 2.78) when compared with the left lobe (5.04 ± 0.82) that suffered ischemia / reperfusion (p = 0.002). Significant differences also occurred when comparing the right (18.04 ± 3.52) and left (7.11 ± 1.86) lobes of the animals of the Andiroba group (p = 0.004). There was no significant difference in dosages of AST, ALT and Gamma- GT when comparing the two groups (p > 0.05). Andiroba oil did not contribute to the protection of liver function in a rat model of liver injury induced by normothermic ischemia and reperfusion.
Highlights
Liver ischemia-reperfusion (I/R) involves a complex series of processes that culminate in hepatocellular injury
We observed that the values of the radioactive uptake in the right liver lobe of animals treated with saline (17.53 ± 2.78) were not statistically different from those recorded in the animals from the Andiroba group (18.04 ± 3.52, p=0.461)
There was no significant difference in the values of %ATI/g of the left liver lobe when the two groups were compared (p=0.083)
Summary
Liver ischemia-reperfusion (I/R) involves a complex series of processes that culminate in hepatocellular injury It is a common consequence of liver surgery, after hepatectomy and liver transplantation, complicated by microcirculatory failure, followed by necrosis and cell death[1]. Several studies have shown anti-inflammatory, analgesic and antiallergic activity of this oil 8,9 It has long been used by Amazon extractivists, Indians and river-side people in cases of bites from venomous animals, to combat helminths, protozoa, hepatitis and other diseases of the liver[3]. Study conducted at the Federal University of Rio Grande do Norte – UFRN in cooperation with the University of the State of Pará – UEPA, Brazil. Assistant Professor , Potiguar University – UnP, Natal, Rio Grande do Norte State – RN, Brazil; 4. The percentage of radioactivity in each sample of liver per gram of tissue (%ATI/g) was calculated by dividing the specific activity by the total radioactivity injected into each animal
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