Abstract
To evaluate the protective effect of remote ischemic per-conditioning in ischemia and reperfusion-induced renal injury. Fifteen rats (Rattus norvegicus) were randomized into three groups (n = 5): Group Normality (GN), Control Ischemia and Reperfusion (GIR) and Group remote ischemic per-conditioning (GPER). With the exception of the GN group, all others underwent renal ischemia for 30 minutes. In group GPER we performed the ischemic remote per-conditioning, consisting of three cycles of ischemia and reperfusion applied every five minutes during the ischemic period, to the left hindlimb of the rats by means of a tourniquet. To quantify the lesions we measured serum levels of creatinine and urea, as well as analyzed renal histopathology. The GPER group presented with better levels of urea (83.74 ± 14.58%) and creatinine (0.72 ± 26.14%) when compared to GIR group, approaching the GN group. Histopathologically, the lower levels of medullary congestion and hydropic degeneration were found in group GPER. The remote ischemic per-conditioning had a significant protective effect on renal ischemia and reperfusion.
Highlights
Ischemia and reperfusion lesions culminate in several deleterious effects for the most different kinds of organs
The present study aims to evaluate the effect of remote ischemic per-conditioning on lesions from kidney ischemia and reperfusion syndrome induced in rats
Ischemic per-conditioning with the Group Normality (GN) group (72.16 ± 9.9%) did not show statistically significant results (p> 0.05)
Summary
Ischemia and reperfusion lesions culminate in several deleterious effects for the most different kinds of organs. Reperfusion is largely responsible for the main lesions in the cells of the ischemic organ. Numerous practical situations in urology converge to the problem of renal ischemia and reperfusion, notably, renal transplantation being the most common occurrence of this type of injury in everyday Urology. Acute renal failure, characterized by abrupt elevation of serum urea and creatinine, has in the ischemia and reperfusion lesion its the main etiological factor[1]. As an alternative to reduce the deleterious effects of kidney ischemia and reperfusion syndrome, various substances have been tried, such as chlorpromazine, verapamil, allopurinol, octreotide, copaiba oil, vitamins C, D and E and cyclosporine A. The effects of the majority of them have been disappointing[1,2]
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