Abstract
The aim of this study was to investigate the effect of resistance training (RT) followed by a similar detraining period on the modulation of oxidative stress (OS) in obese older women. Fourteen obese women (age: 68.7 ± 4.8 years, body mass: 71.3 ± 14.8 kg, height: 156.3 ± 7.2 cm, body fat: 44.3 ± 4.4%) were submitted to 12 weeks of a RT program followed by a similar detraining period. Advanced oxidation protein products (AOPP) and total radical-trapping antioxidant potential (TRAP) were used as oxidative stress indicators. AOPP was not changed by RT or detraining (P = 0.31). Furthermore, TRAP was increased with RT (+ 15.1%; P < 0.001) and remained high even after 12 weeks of detraining (10.5%; P < 0.001). The results suggest that OS can be improved by RT and the 12-week detraining period does not seem to be enough to reverse adaptations induced by RT in obese older women.
Highlights
Oxidative stress (OS) is a phenomenon characterized by an imbalance between the generation of free radicals (FR) and oxygen and nitrogen reactive species (ROS / RNS), and the inability to neutralize them by an antioxidant defense system[1]
Muscular strength has been significantly reduced after 12 weeks of detraining (P < 0.05), the results were higher than those found at baseline in chest press (10.6%), while a decrease was identified in knee extension (-5.5%)
trapping antioxidant potential (TRAP) increased after Resistance training (RT) (+15.1%, effect size (ES) = 0.94; P < 0.001) and remained high even after a 12-week detraining period (+10.5%; P < 0.001)
Summary
Oxidative stress (OS) is a phenomenon characterized by an imbalance between the generation of free radicals (FR) and oxygen and nitrogen reactive species (ROS / RNS), and the inability to neutralize them by an antioxidant defense system[1]. This imbalance can damage the cell membrane and lead to oxidation of important macromolecules responsible for providing energy and tissue repair, such as carbohydrates, proteins and lipids[1]. RT has been indicated as part of weight control programs, in particular, for the treatment of obesity[6], since it increases the resting metabolic rate, helps in the retention of muscle mass and has a positive effect on the oxidative balance, improving the antioxidant capacity and decreasing the deleterious effects of ROS / RNS7
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