EFECTS OF LISINOPRIL AND AMLODIPIN IN COMBINATION FOR THE TREATMENT OF HYPERTENSION WITH PULSE WAVE VELOCITY VP PLUS 1000 METER

Abstract

Aim: The aim of this study was to evaluate the antihypertensive efficacy of lisinopril and amlodipine in combination which were measured by the pulse wave velocity meter. Research objects and Methods: 40 patients with primary hypertension, mean age 69.18 ± 10.4 years. All patients had their blood pressure, pulse wave velocity (baWPV), ankle brachial index measured by pulse wave velocity VP Plus 1000 meter before receiving the treatment. All patients were then given the Lisonorm combination pill (lisinopril 10 mg and amlodipine 5 mg) for 4 weeks. After 4 weeks, the patients was measured again with the same device (the pulse wave velocity of VP Plus 1000 meter). Results: After 4 weeks, the values of the Right arm blood pressure decreased: 26.58 ± 9.51 mmHg/ 8.6 ± 4.47 mmHg; Left arm blood pressure decreased: 26.88 ± 11.27/13.55 ± 8.15mmHg; Right ankle blood pressure decreased: 23.75 ± 11.78/10.75 ± 6.64mmHg; Left ankle blood pressure decreased: 30.33 ± 16.64/13.6 ± 9.28mmHg; The rate of patients with the target blood pressure was 72.5% (29/40 patients). Right baPWV decreased 593.65 ± 416.59 cm/s; Left baPWV decreased 585.4 ± 447.19 cm/s. Conclusion: The combination of lisinopril 10mg and amlodipine 5mg effectively had decreased the blood pressure in both extremities and pulse wave velocity, and had reduced vessel wall stiffness when it was measured by the pulse wave velocity VP Plus 1000 meter.