Efectos del alcohol sobre el metabolismo a través de la acetil-Coenzima A sintetasa: revisión sistemática y metanálisis

Abstract

Objective: To evaluate the effects of alcohol on the metabolism of the acetyl-Coenzyme A synthetase pathway. Methods: For this meta-analysis, articles published up to December 2019 were searched and the levels of phosphorylated adenosine, acetate, acetyl-CoA, acetoacetate and acetyl-CoA activity were evaluated. The standardized mean difference and the weighted mean from the meta-analysis were compared using the random model. Results: Alcohol promoted an increase in the levels of adenosine triphosphate, adenosine diphosphate, adenosine monophosphate and inorganic phosphate (odds ratio [OR] = 1.16; 95% confidence interval [CI], 0.42, 2 .10; p = 0.003). In addition, the levels of acetate, acetoacetate and acetyl-CoA increased due to alcohol (OR = 2.05; 95% CI, 1.07, 3.04; p < 0.0001), however, with high heterogeneity (I² = 77%). Acetyl-CoA synthetase (ACSS2) activity increased after alcohol administration (OR = 2.07; 95% CI, 0.16, 3.97; p = 0.03), with high heterogeneity (I² = 88%). Final considerations: Alcohol has a supplementary effect on this metabolic pathway, but in a restricted way. Furthermore, ACSS2 activity increased after exposure to alcohol. However, these effects of alcohol were time dependent.