Efecto de la inflorescencia de “coliflor” sobre síndrome caquéctico en Mus musculus var. swiss con cáncer inducido

Abstract

The objective was to determine the effect of Brassica oleracea var Botrytis "cauliflower" inflorescences on cachectic syndrome in Mus musculus var. swiss with induced cancer. Cachectic syndrome is characterized by progressive loss of body weight, anorexia, asthenia, immunosuppression and metabolism of carbohydrates, lipids and proteins, with loss of muscle and adipose tissue. It used dry cauliflower inflorescence extract (ESC) and male mice 35-45 g with induced cancer, divided into groups: G1 untreated control, G2 and G3 treated with ESC, doses 10 and 20mg/kg/bw/vo and G4 treated with quercitin, dose 7.14mg/Kg/bw/vo for 90 days. Some manifestations of cachectic syndrome were determined. It was observed that G1 had thinning and progressive increase in alopecia, asthenia and conjunctival xerosis due to energy and metabolic imbalance compared to G2, G3 and G4 that had higher body weight and fewer cachectic manifestations, being significant by time and treatment group (P<0.01). It has been reported that cauliflower contains flavonoids quercitin and kaemferol, with anti-inflammatory properties for its action on cyclooxygenase, lipooxygenase, interleukins and chemosins, with antioxidant properties on intracellular glutathione, in redox reactions and favoring the expression of caspases in cell apoptosis. Therefore, it is concluded that cauliflower prevents body weight loss and decreases cachectic syndrome because it contains kaempferol and quercitin that act synergistically with anti-inflammatory, antioxidant and anticancer properties.