Abstract
Pain is a public health problem. Its pharmacological treatment is performed through conventional synthetic drugs (non-opioid analgesics and opioids), which have negative effects at the liver, gastric and renal levels. Less aggressive alternatives which use different plant species are under study. Lactuca sativa is a plant used as a popular remedy to treat insomnia, stomach problems, pain and inflammation. Its extracts have been evaluated pharmacologically as anticonvulsant, sedative-hypnotics and antioxidants, mainly in animal models. A study was carried out to evaluate the analgesic property of two topical pharmaceutical forms elaborated with Lactuca sativa extract, for the alternative treatment of patients with acute muscular pain. Through a randomized, controlled clinical trial, a cream and gel at 10% extract were evaluated. Pain was assessed using the modified Wong-Baker Facial Expression Scale at the beginning and end of treatment, as well as the degree of relief and adverse reactions. Both products are an alternative for the treatment of acute pain versus the use of conventional synthetic drugs.
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