Abstract
1. 1. The influence of the intravenous administration of catecholamines and a β adrenergic blocking agent on short-circuit current ( I s ) skin resitance and sodium flux was studied with living anesthetized frog. 2. 2. Epinephrine (α plus β adrenergic stimulation) adn isoproterenol (β stimulation) produced an increase of I s , which was not explained by sodium transport changes, and mucous release. 3. 3. In contrast to epinephrine, isoproterenol decreased skin resistance and increased sodium outflux. 4. 4. Pronethalol (a β adrenergic blocking agent) decreased I 3, net sodium flux, and increased skin resistance. 5. 5. The results indicate that ion transport across the skin, in vivo, is influenced by α and β adrenergic stimulation. They support the concept that the two stimuli produce opposing effects on sodium transport, i.e. α stimulation decreases and β stimulation increases sodium permeability of the skin.
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