Abstract
Efavirenz-loaded polymeric nanocapsules: Formulation, development, and validation of an RP-UHPLC-DAD method for drug quantification, determination of encapsulation efficiency, stability study, and dissolution profile
Highlights
Polymeric nanocapsules have been recognized as promising drug carrier systems and the use of efavirenz (EFV)loaded delivery systems is a suitable strategy for the treatment of acquired immunodeficiency syndrome, as these formulations can improve the dissolution profile, prolong the pharmacological effect, lead to a decrease in dosage, and, reduce side effects (Dimer et al, 2020; Lyra et al, 2017; Patel et al, 2013; Varshosaz et al, 2018)
This study aims at preparing efavirenz (EFV)-loaded polymeric nanocapsules and carrying out the analytical method development and validation in order to provide a suitable tool for evaluating these formulations in terms of encapsulation efficiency, stability, and dissolution profile
To the best of our knowledge, this is the first report about the stability of polymeric nanoformulations containing EFV.Taking all these into account, this study aimed to obtain EFV-loaded nanocapsules based on poly(ε-caprolactone) (PCL) and [poly(ethylene glycol) 6000] (PEG) and to describe the validation of a rapid UHPLC assay for the EFV determination in these formulations
Summary
Polymeric nanocapsules have been recognized as promising drug carrier systems and the use of efavirenz (EFV)loaded delivery systems is a suitable strategy for the treatment of acquired immunodeficiency syndrome, as these formulations can improve the dissolution profile, prolong the pharmacological effect, lead to a decrease in dosage, and, reduce side effects (Dimer et al, 2020; Lyra et al, 2017; Patel et al, 2013; Varshosaz et al, 2018). Induri et al (2016) validated a UHPLC-photodiode array detector (DAD) method for simultaneous quantification of EFV and lamivudine in tablets using a mobile phase containing 10 mM phosphate buffer (pH = 4.0) and 10.0% acetonitrile in methanol. Dos Santos Martins et al (2020) reported a validation method for EFV determination in plasma by UHPLC-DAD This method involved the addition of the plasma precipitation using acetonitrile and solvent evaporation. No paper is provided by literature regarding the validation of a UHPLC method to determine EFV in polymeric nanocapsules by a fast and simple UHPLC method
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
