Abstract
A link between oedema and eosinophils: eosinophilic fasciitis A 65-year-old man presented with progressive swelling in his 4 limbs. The skin on his limbs was oedematous and indurated, with an orange peel skin and blistering in some places, as well as a groove sign over the tibia. Lab results showed a remarkable eosinophilia of 23% (reference ≤ 6%). A deep skin biopsy revealed fascial infiltration and fibrin deposition, consistent with eosinophilic fasciitis (EF). EF is a rare cause of fasciitis, eosinophilia and polyclonal hypergammaglobulinemia. Because of its rarity, diagnostic delay is usually significant. Corticosteroids are the mainstay of therapy, but because of an incomplete response and the need for long-term treatment, corticosteroid sparing agents are often associated.
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